Allele-specific real-time PCR testing for minor macrolide-resistant Mycoplasma Pneumoniae
نویسندگان
چکیده
منابع مشابه
Clinical evaluation of macrolide-resistant Mycoplasma pneumoniae.
Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumoniae infection (MR patients) treated with macrolides were compared with those ...
متن کاملMacrolide-Resistant Mycoplasma pneumoniae, United States1
M are the preferred treatment for infections caused by Mycoplasma pneumoniae in children (1). Since 2000, macrolide resistance has developed in Asia and has now been reported from many parts of the world (2). This resistance is of a high level and has been associated with longer duration of fever, cough, and hospital stay and the need to switch to alternative antimicrobial agents (3– 5). Scant ...
متن کاملMacrolide-resistant Mycoplasma pneumoniae in paediatric pneumonia.
Mycoplasma pneumoniae is one of the most common causes of bacterial community-acquired pneumonia (CAP) in paediatrics, and can lead to severe and long-lasting disease [1]. Macrolides are usually considered the first-choice antimicrobials for M. pneumoniae CAP in children because the alternatives (i.e. fluoroquinolones and tetracyclines) are not approved for use in the first years of life [2]. R...
متن کاملThe fall of the Macrolide: Macrolide-resistant Mycoplasma pneumoniae
Mycoplasma pneumoniae (M. pneumoniae) is a major cause of community-acquired pneumonia (CAP) in children, accounting for 10-30% of the etiological agents wor ldwide. Yet , the epidemio logy of M. pneumonia-associated CAP in Hong Kong remains unknown for several reasons. First, there is no systemic surveillance of agents causing CAP in place in Hong Kong. Secondly, serology was the mainstay of d...
متن کاملDevelopment of a multiplex real-time PCR assay for detection of Mycoplasma pneumoniae, Chlamydiapneumoniae and mutations associated with macrolide resistance in Mycoplasma pneumoniae from respiratory clinical specimens
The aim of this study was to improve detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in clinical specimens by developing a multiplex real-time PCR assay that includes identification of macrolide-resistant M. pneumoniae. Novel assays targeting a M. pneumoniae conserved hypothetical protein gene, M. pneumoniae 23S rRNA gene mutations associated with macrolide resistance and human β-gl...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2019
ISSN: 1471-2334
DOI: 10.1186/s12879-019-4228-4